A Study on Pre-Induction Cervical Ripening with PGE2 Vaginal Tablet One (3 mg) vs. Half (1.5 mg) in Low Risk Multi Parous Mothers at 40 Weeks of Gestation

摘要

Backgrounds: Induction of labor is a common practice. In women with immature cervix, PGE2 is commonly used for pre-induction. We hypothesized that PGE2 1.5 mg may be equally effective to PGE2 3 mg in multiparous women for labor induction. The present effort was an attempt to compare the efficacy and effects of pre-induction cervical ripening with PGE2 3 style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">mg vs style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">. style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> 1.5>>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">mg in multi-parous mothers (2nd and 3rd Pregnancy) at 40 weeks.>>> style="font-family:""> >>> style="font-family:""> style="font-family:Verdana;">Methods: A style="font-family:Verdana;">double style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">- style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">blind>>> style="font-family:""> style="font-family:Verdana;"> randomized controlled trial was carried out at Castle Street Hospital for Women, Colombo, Sri Lanka. Study subjects consisted of women with singleton pregnancy (no cesarean history) admitted for delivery at 40 weeks of their 2 style="font-family:Verdana;">nd>>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">or 3rd pregnancy. PGE2 1.5>>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">mg vs style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">. style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> 3>>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">mg PGE2 vaginal tablet style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">were>>> style="font-family:""> style="font-family:Verdana;"> used for treatment (n = 173) and control (n = 170) groups, respectively. Cervical ripening and maternal, fetal complications were observed. Unfavorable cervices were induced with the same PGE2 dose style="font-family:Verdana;">in style="font-family:Verdana;"> the following day. Results: Study group, compared with the control group, achieved the same rate of favorable cervices in 1st and 2nd cycles (63.5 style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">% style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> vs style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">.>>> style="font-family:""> style="font-family:Verdana;"> 64%, respectively). Both groups showed the same rate of cervical dilatation style="font-family:Verdana;">achievement, style="font-family:Verdana;"> and admissions to style="font-family:Verdana;">Special style="font-family:Verdana;"> Care Baby Unit. Study group showed significantly less maternal complications (4% and 11%,