A recent study published in Nature by the Maus group represents a great discovery that the IFNγR pathway in solid tumors affected interactions with CAR T cells by affecting cell-binding duration and avidity.1 Adoptive cell therapy,particularly chimeric antigen receptor(CAR)T therapy,has shown significant clinical success in leukemia,lymphoma,and multiple myeloma patients.However,CAR T cell mediates solid tumor therapy with no equivalent successes in patients.
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机译:Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells against solid tumor
机译:Retraction statement: ‘Formin‐like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer’ by Yuanfeng Zeng Huijun Xie Yudan Qiao Jianmei Wang Xiling Zhu Guoyang He Yuling Li Xiaoli Ren Feifei Wang Li Liang and Yanqing Ding