Anti-inflammatory and Scalp Care Efficacy of a Multi-herb Extraction against Malassezia furfur

摘要

Malassezia furfur is a lipophilic and dermatological pathogenic yeast,which normally exists on human skin,and causes tinea versicolor,seborrhoeic dermatitis,and atopic dermatitis,especially on human scalp.The multi-herb extraction VGP which consists of Vitex trifolia fruit,Gentiana scabra,and Polygonum multiflorum root extract was used to study its effect of anti-inflammation,controlling sebum and dandruff on scalp care.Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur,VGP can inhibit the expression of interleukin 6(IL-6),prostaglandin E2(PGE-2),monocyte chemoattractant protein 1(MCP-1)and interleukin 1β(IL-1β)in a dose-dependent manner under 0.01%to 0.125%concentration.On the inflammatory model of 3D reconstructed skin induced by H2O2,VGP significantly improved the cell viability and skin structure,and reduced the production of interleukin 8(IL-8),PGE-2,and leukotriene B4(LTB4).During 4 week’s treatment with test shampoo contained 0.5%VGP thrice a week on 16 subjects met with different symptom,VGP reduced the sebum content and TEWL,improved the redness,itching and dandruff on human scalp skin.Therefore,as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation.