Screening of SARS-CoV-2 in 299 Hospitalized Children with Hematooncological Diseases:A Multicenter Survey in Hubei,China

摘要

Summary:The SARS-CoV-2 infection status of hospitalized children was surveyed in the department of pediatric hematology and oncology in three different hospitals of epidemic areas in Hubei,China.A cross-sectional study was performed to investigate the clinical characteristics,lung CT scan,SARS CoV-2 nucleic acid test and serum antibodics of hospitalized children with hemato-oncological diseases from January 23 to April 24,2020.299 children were enrolled in this study,including 176 males(58.9%)and 123 females(41.1%),aged from 2 months to 16 years.255 cases(85.3%)received chemotherapy or other immunosuppressive therapies,and there were 44 cases(14.7%)of other benign diseases.Nucleic acid test was performed on 258 children(86.3%)and one case was positive.163 cases(54.5%)were tested for serum antibodies,and all of them were negative.Lung CT scan was performed on 247 children(82.6%),and 107 of them showed infectious changes.Only one case(0.33%)of COVID-19 was diagnosed in the group.The prevalence rate of COVID-19 in enrolled children with hemato-oncological diseases in Hubei was 0.33%.Immunosuppressed patients are not prone to produce related antibodies.Comprehensive protective measures and ward management can reduce the risk of SARS-CoV-2 infection in the group patients.