我国糖尿病与阿尔茨海默病关联性的Meta分析

摘要

Objective To determine the relationship between diabetes and Alzheimer disease. Methods The references were retrieved through the databases of Medline, CBM, CNKI and so on, Meta-analysis was chosen to analyze the data from references by RevMan version 4.2. Results Eight studies were included in this review. The involved subjects were 6 101, composing patients group 944 cases and control group 5 157. The relationship between diabetes and Alzheimer disease was analyzed by fixed effects model. Their pooled OR and 95％ CI were 1.77 (1.34-2.34) ( P ＜0. 01 ). The analytical result of sensitivity proved that the results of Meta-analysis were coherent. Conclusion Diabetes might be associated with Alzheimer disease,and was one of the risk factors for Alzheimer disease.%目的 探讨糖尿病与阿尔茨海默病的关系.方法 通过Medline、中国生物医学文献数据库和中国学术期刊全文数据库等数据库搜集资料,应用RevMan 4.2软件对所得资料进行Meta分析.结果 有8篇文献进入Meta分析,共获得6 101例样本,其中病例组944例,对照组5 157例.经过Meta分析,采用固定效应模型,合并OR值和95%的可信区间为1.77(1.34～2.34)(P<0.01);敏感性分析结果提示,采用不同模型的Meta分析结果一致.结论 糖尿病与阿尔茨海默痛可能具有关联性,它是阿尔茨海默病发生的一个危险因素.