Experimental study on the protective effect of propofol on liver injury in rats with sepsis

摘要

Objective:To observe the protective effect of propofol on liver injury in rats with sepsis and explore its protective mechanism.Methods:24 Wister rats were randomly divided into 3 groups,with 8 rats in each group:the sham operation group,the saline group and the propofol group.An intraperitoneal injection of LPS 8 mg/kg was used in the saline group,with continuous infusion of normal saline.An intraperitoneal injection of LPS 8 mg/kg and continuous infusion of propofol saline solution were also performed in the propofol group.Results:Compared with the saline group,the levels of ALT,AST,IL-6 and TNF-αin the sham operation group and the propofol group were significantly lower than those in the saline group.Conclusions:Propofol has a certain protective effect on liver injury in rats with sepsis.