The study of relationship between the expression of VEGF and Ang-2 and Tie-2 in endometriosis

摘要

Objective:To detect the expression of VEGF(vascular endothelial growth factor),Ang-2(angiopoietin-2)and Tie-2 in endometriosis(EMs)and their correlations with menstrual cycle and clinical stage.Methods:Thirty specimens of normal endometrium,eutopic endometrium and ectopic endometrium tissues were collected.The expression of VEGF,Ang-2 and Tie-2 was detected by immunohistochemistry methods.Results:The positive rate of expression of VEGF in the normal endometrium,eutopic endometrium and ectopic endometrium tissues gradually increased(16.67%,86.67%,90.00%),compared three groups(p<.01).The positive rate of expression of Ang-2 in the normal endometrium,eutopic endometrium and ectopic endometrium tissues was 33.33%,70.00%,60.00%,respectively(p<.05).The positive rate of expression of Tie-2 in the normal endometrial,eutopic endometrium and ectopic endometrial tissues was 13.33%,50.00%,40.00%,respectively(p<.01).The expression of VEGF,Ang-2 and Tie-2 was closely correlated with each other(r=0.875,r=0.905,r=0.898).Conclusions:Our findings suggest that there is a close relation between VEGF,Ang-2 and Tie-2,the up-regulation of VEGF and Ang-2 may cooperatively contribute to survival and invasion of EMs.This may provide new targets for therapy of EMs.