The study of relationship between the expression of VEGF and Ang-2 and Tie-2 in endometriosis

摘要

Objective: To detect the expression of VEGF (vascular endothelial growth factor), Ang-2 (angiopoietin-2) and Tie-2 in en-dometriosis (EMs) and their correlations with menstrual cycle and clinical stage. Methods: Thirty specimens of normal endometrium, eutopic endometrium and ectopic endometrium tissues were collected. The expression of VEGF, Ang-2 and Tie-2 was detected by immunohistochemistry methods. Results:The positive rate of expression of VEGF in the normal endometrium, eutopic endometrium and ectopic endometrium tissues gradually increased (16.67％, 86.67％, 90.00％), compared three groups (p<.01). The positive rate of expression of Ang-2 in the normal endometrium, eutopic endometrium and ectopic endometrium tissues was 33.33％, 70.00％, 60.00％, respectively (p<.05). The positive rate of expression of Tie-2 in the normal endometrial, eutopic endometrium and ectopic endometrial tis-sues was 13.33％, 50.00％, 40.00％, respectively (p<.01). The expression of VEGF, Ang-2 and Tie-2 was closely correlated with each other (r=0.875, r=0.905, r=0.898). Conclusions: Our findings suggest that there is a close relation between VEGF, Ang-2 and Tie-2, the up-regulation of VEGF and Ang-2 may cooperatively contribute to survival and invasion of EMs. This may provide new targets for therapy of EMs.