微通道反应器合成纳米BaSO4颗粒及其在干片多功能层上的应用

摘要

以BaCl2和Na2SO4为原料,采用微通道反应器制备得到立方形纳米BaSO4颗粒,并通过SEM、XRD对其进行表征.考察了不同反应方式及微通道反应器结构、反应物体积流量、反应物浓度、反应温度、体积流量比对纳米BaSO4颗粒大小和形貌的影响.实验结果表明:25℃下,体积流量为2.5 ml/min,反应物浓度为0.1 mol/L,体积流量比为5是应用于淀粉酶医用干片多功能层的纳米BaSO4颗粒合成的最佳反应条件.与直接沉淀法相比,微通道反应器内制备出的纳米BaSO4颗粒形貌规整,最终得到产物粒径为25～55 nm.将所制备的BaSO4多功能层应用到淀粉酶医用干片中,颜色梯度明显,经反射光密度仪检测,信号值依次减小,且信号值变化曲线重复性、稳定性较好,说明制备的BaSO4颗粒可应用于淀粉酶体外诊断试剂中多功能层上.%BaCl2 and Na2SO4 were used as raw materials to prepare cubic nano-BaSO4 particles by microchannel reactor, and characterized by SEM and XRD. The effects of different reaction methods and microchannel reactor structures, volume flows of reactants, the concentration, temperature, volume flow ratio on size and morphology of BaSO4 nanoparticles were investigated. The suitable reaction condition applied to multifunctional layer of amylase medical dry film was obtained with volume flow of 2.5 ml/min, reactant concentration of 0.1 mol/L, the temperature of 25℃ and volume flow ratio of 5. At the same time, compared with the direct precipitation method, the nanoBaSO4 particles prepared in the microchannel reactor had a regular morphology with particle size from 25 nm to 55 nm. The prepared BaSO4 multi-functional layers were applied to the amylase medical slides with an obvious color gradient. The signal value decreased in turn using the densitometer, and the repeatability and stability of signal value curve were better, which indicated that the prepared BaSO4 particles could be applied to the multi-functional layer of the amylase in vitro diagnostic reagent.