慢性肺源性心脏病急性加重期患者红细胞的血液流变学和生物力学特性研究

摘要

目的 探讨慢性肺源性心脏病(简称肺心病)急性加重期患者血液流变学参数和红细胞生物力学特性.方法 分别测定40例慢性肺心病急性发作期患者(肺心病组)和38例正常人(对照组)血液流变学参数和红细胞弹性模量、黏性系数、表面积/体积等.结果 (1)慢性肺心病急性加重期患者血液呈高黏状态,全血和血浆黏度增加,聚集指数增加,血沉加快,红细胞变形指数降低.(2)肺心病组患者与对照组比较,红细胞表面积/体积降低,红细胞膜弹性模量、黏性系数增加.结论 慢性肺心病急性加重期患者红细胞变形性明显下降,这可能与其几何形状和细胞膜黏弹性异常,不利于变形有关.%Objective To compare erythrocyte hemorheology and biomechanics properties in acute phase patients with chronicpulmonary heart disease with healthy controls.Methods In the venous blood 40 acute phase patients with chronic pulmonary heartdisease and 38 healthy controls,the erythrocyte hemorheology parameter, modulus of elasticity,viscous coefficient,the ratio of sur-face area/volume were determined.Results (1)The blood of acute phase patients with chronic pulmonary heart disease was in thehyperviscosity state.The blood viscosity, plasma viscosity, hematocrit, aggregation indexes, erythrocyte sedimentation were highercompared with healthy controls, but erythrocyte deformability index was decreased.(2)In the acute phase patients with chronic pul-monary heart disease,the ratio of erythrocyte surface/volume was decreased, membrane elastic modulus and viscous coefficients erythrocytes were increased.Conclusion The decrease of erythrocyte deformability of the acute phase patients with chronic pulmo-nary heart disease maybe result from the abnormal of geometry and membrane viscoelastic properties.These abnormal will be unfa-vorable to erythrocyte deformability.