立体定向放射治疗肝转移癌的疗效分析

摘要

目的：评价立体定向放疗在肝转移癌治疗中的临床价值及不良反应。方法42例在该科进行钴60立体定向放疗的肝转移癌患者（转移病灶小于或等于3个，单个病灶小于或等于5 cm ），50％等剂量曲线包绕靶区，每次3．5～4．5 Gy ，共10次。统计分析其中位生存期、局部控制率、并发症及放射性肝损伤。结果全组患者中位生存期为7．9月，完全缓解2例，部分缓解27例，局部控制率为69％，无一例发生重度放射性肝损伤。结论立体定向放疗是治疗肝转移癌的安全、有效手段。%Objective To evaluate the clinical value of stereotactic radiotherapy for the treatment of metastatic hepatic carcino-ma .Methods 42 patients with metastatic hepatic carcinoma (metastases≤3 ,maximum tumor diameter≤5 cm)were treated with Co60 stereotactic radiotherapy alone .The prescription isodose of PTV was 3 .5-4 .5 Gy ,total 10 times ,the median survival time ,lo-cal control ,complication and RILD(radiation-induced liver disease) of the patients were assessed .Results The median survival date was 7 .9 months ,2 cases were complete remission ,the local control rates was 69% ,27 cases were partial remission ,and there was no serious adverse side effect ,such as severe radiation-induced hepatic injury .Conclusion The stereotactic radiotherqpy was a good choice for inoperable metastatic hepatic carcinoma .