Objective To investigate the relation between the negative emotions and the quality of life in lung cancer patients with palliative care .Methods 198 cases (lung cancer group) of lung cancer treated with palliative care in the Fourth Hospital affili -ated to Hebei Provincial Medical University from 2007 to 2010 were investigated to find the correlation between the negative emo -tions and the quality of life by using the Self-Rating Depression Scale(SDS) ,the Self Rating Anxiety Scale (SAS) and the Quality of Life Questionnaire(QLQ-C30).Contemporaneous 100 individuals with healthy physical examination were selected as the control group .The scores of the negative emotions were compared between the two groups .Results The SDS and SAS scores were 39 .24±8 .64 and 36 .44±7 .61 in the lung cancer group ,and 26 .53±9 .43 and 31 .42±7 .54 in the control group ,the SDS and SAS scores in the lung cancer group were significantly higher than those in the control group with statistical difference (P<0 .05) .The score of the overall quality of life(QL) was 59 .54±12 .45 ,within the poorer range .The negative emotions in the lung cancer group were negatively correlated with the total QL and the functional scores (r= 0 .46 , r= 0 .39 ,P<0 .05) ,and positively correlated with the symptoms scores(r=0 .30 , P<0 .05) .The depression and anxiety scores in the lung cancer group were negatively correlated with the overall QL and the functional score (r= -0 .45 , r= -0 .38 and r= -0 .36 , r= -0 .38 ,P<0 .05) ,and positively correlated with the symptom scores (r=0 .28, r=0 .27 , P<0 .05 ) .Depression and anxiety had strong correlation (r=0 .74 , P<0 .05) . The multivariate Logistic regression analysis showed that depression (β= -1 .87 ,OR=0 .15) and anxiety(β= -1 .36 ,OR=0 .26) and the total negative emotions (β= -2 .35 ,OR=0 .10) had significantly negative effect on the quality of life(P<0 .05) .Conclusion The negative emotions of lung cancer patients with palliative care are important factors influencing the quality of life . Improving their negative emotions through multiple angles can increase the quality of life.%目的 探讨和分析肺癌患者姑息治疗中的负性情绪和生活质量的相关性.方法 对2007年至2010年在河北省医科大学附属第四医院住院的198例姑息治疗的肺癌患者(肺癌组)进行调查,采用抑郁自评量表(SDS)、焦虑自评量表(SAS)和生活质量核心问卷量表(QLQ-C30),分析负性情绪与生活质量的相关性;选择同期100例进行健康体检的自愿者作为对照组,并比较两组负性情绪得分情况.结果 肺癌组SDS得分为(39.24±8.64)分,SAS得分为(36.44±7.61)分;对照组SDS得分为(26.53±9.43)分,SAS得分为(31.42±7.54)分,肺癌组SDS和SAS得分显著高于对照组,差异有统计学意义(P<0.05).肺癌组患者整体生活质量量表(QL)得分为(59.54±12.45)分,属于较差范畴.肺癌组患者的负性情绪与整体QL和功能评分呈负相关(r=-0.46和r=-0.39,P<0.05),与症状评分呈正相关(r=0.30,P<0.05);且肺癌组患者的抑郁、焦虑与整体QL和功能评分呈负相关(r=-0.45、r=-0.38和 r=-0.36、r=-0.38,P<0.05),与症状评分呈正相关(r=0.28、r=0.27,P<0.05).抑郁和焦虑之间有较强的相关性(r=0.74,P<0.05).多因素Logistic回归分析的结果显示,抑郁(β=-1.87,OR=0.15)、焦虑(β=-1.36,OR=0.26)和整体负面情绪(β=-2.35,OR=0.10)对生活质量有着显著的负面影响(P<0.05).结论 姑息治疗的肺癌患者的负性情绪是影响生活质量的重要因素,可以通过多角度改善其负性情绪来提高其生活质量.
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