IL-6基因多态性与类风湿性关节炎易感性关系的系统评估

摘要

目的：系统评估国人白细胞素‐6（IL‐6）基因多态性与类风湿性关节炎（RA ）易感性的关系。方法计算机检索Pubmed 、Cochrane library 、Sciverse 、CNKI 、VIP 、CBM 及万方数据库，检索时间均从建库至2013年9月。获取 IL‐6基因多态性与RA 易感性关系的病例对照研究。由2名研究者独立筛选文献。 Meta 分析采用 Revman 5．0软件处理，采用 Stata 11．0软件评估发表偏倚。结果共纳入3个病例对照研究。 Meta 分析显示：IL‐6‐174基因多态性 G 等位基因和隐性模型（GG vs ．GC ＋ CC）与RA 易感性存在一定的关系（均 P＜0．01），然而显性模型（GG ＋ GC vs ．CC）和纯合型（GG vs ．CC）却不表现出此联系作用（P＝0．18，P＝0．13）。在 IL‐6‐572多态性位点中，纯合型、隐性模型、显性模型及等位基因均与 RA 易感性不相关（P ＝0．64，0．92，0．05）。结论国人 IL‐6‐174G／C 基因多态性 G 等位基因和隐性模型与 RA 的易感性可能相关。%Objective To systematically evaluate the association between interleukin‐6 gene polymorphism and rheumatoid ar‐thritis(RA) susceptibility in countrymen .Methods Case‐control studies(CCS) on the association between interleukin‐6 gene poly‐morphism and rheumatoid arthritis susceptibility in countrymen were retrieved by computer from Pubmed ,Cochrane library ,Sci‐verse ,CNKI ,VIP ,CBM and Wanfang database from their establishment to Sep ,2013 .According to the inclusion and exclusion crite‐ria ,two reviewers independently screened the CCS .The meta analysis adopted the Revman 5 .0 software ,the publication bias was assessed by the Stata 11 .0 software .Results A total of three CCS were included .The meta analysis revealed that G allele and re‐cessive model(GG vs .GC + CC) of the IL‐6‐174 gene polymorphism had certain relation with RA susceptibility (P < 0 .01 ,P <0 .01) ,but the dominant models(GG + GC vs .CC) and homozygote type(GG vs .CC) did not show this relation(P = 0 .18 ,P =0 .13) .In the IL‐6‐572C/G polymorphism sites ,the homozygote type ,recessive models ,dominant models and alleles had no relation with the RA susceptibility(P = 0 .64 ,0 .92 ,0 .05 ,respectively ) .Conclusion The G allele and recessive models of IL‐6‐174 G /C gene polymorphism may be associated with the RA susceptibility in countrymen .