唾液酸化Lewis X表达对三阴性乳腺癌复发的影响

摘要

目的：探讨唾液酸化 Lewis X（SLeX）表达对三阴性乳腺癌（TNBC）患者肿瘤复发的影响。方法以符合条件的162例TNBC患者为研究对象。临床病理特点从病历获得，随访以电话随访为主，辅以住院随访、门诊随访。生存率估算应用 Kap-lan-Meier法，组间生存率曲线差异采用 Log-rank检验。结果26例（16．0％）SLeX阳性（阳性组），136例（84．0％）SLeX阴性（阴性组）。阳性组有较高的 pN分期。阳性组和阴性组的5年无复发生存（RFS）率分别为65．6％和85．8％，2组的RFS曲线存差异有统计学意义（P＜0．05）。多因素分析表明 RFS率与年龄、pN分期、SLeX表达状态相关（P＜0．05）。结论 SLeX阳性与三阴性乳腺癌患者复发有一定关系。%Objective To explore the impact of sialyl Lewis X(SLeX)expression on tumor recurrence in patients with triple negative breast cancer(TNBC).Methods This study was a retrospective cohort study on 162 hospitalized TNBC patients meeting the conditions.Clinical and pathological characteristics were acquired from medical records.The main form of follow-up was tele-phone follow-up,supplemented by patient follow-up and out-patient follow-up.Kaplan-Meier method was used to estimate the sur-vival rate.The survival difference between the two groups was compared by the Log-rank test.Results A total of 2 6 patients (16.0%)were SLeX-positive(SLeX positive group)and 136 patients(84.0%)were SLeX-negative(SLeX negative group).SLeX positive group were more likely to present with advanced pathologic nodal stage.The 5-year RFS rate were 65.6% and 85.8% in SLeX positive group and SLeX negative group,respectively.RFS curves of the two groups were significantly different(P<0.05). Multivariate analysis showed that RFS was significantly associated with age,pN stage and SLeX expression status(P<0.05).Con-clusion SLeX positive expression is an independent risk factor for tumor relapse in patients with triple-negative breast cancer, which has a certain significance for further risk stratification and targeted therapy.