Superior ligand for Pd(Ⅱ)-catalyzed enantioselective arylation of C(sp^3)-H bonds:chiral acetyl protected aminoethyl quinoline

摘要

Enantioselective functionalization of prochiral C-H bonds is a highly attractive strategy for the construction of chiral compounds.Despite extensive efforts[1],enantioselective C(sp^3)-H functionalization still remains challenging at present.For instance,although enantioselective C-H functionalization via desymmetrization of two carbon centers has been accomplished with Pd catalysis and a directing group,differenciation of the prochiral C-H bonds on one methylene carbon center has rarely been achieved.On a different front,introduction of a transient chiral directing group is expected to be useful in enantioselective C-H arylation of C(sp^2)-H bonds.Nevertheless,transient amino acid directing group