Objective To determine the correlation between the age and urinary 1-hydroxypyrene (1-OHP) and its interaction with the prevalence of hypertension in coke-oven workers, and to investigate the possible mechanism of hypertension in coke-oven workers. Methods A total of 343 coke-oven workers in a coking plant in Shanxi Province were included as the subjects. A unified questionnaire was used to collect personal information. The blood pressure at the resting state was measured 3 times. The concentration of urine 1-OHP was determined by high performance liquid chromatography (HPLC). Results The subjects were divided into low exposure group (≤1.52 μmol/molCr), middle exposure group (>1.52-3.88μmol/molCr) and high exposure group (≥3.88 μmol/molCr) according to the urine 1-OHP concentration. The prevalence of hypertension was 13.6%, 17.5% and 27.7%, respectively. The prevalence of hyper-tension in the high exposure group was significantly higher than that in the low exposure group, and there was statisti-cally significant difference (P35 years of age and high exposure were the risk factors of hypertension, and there was positive interaction of multiplicative model between them. The OR (95%CI) was 6.800 (2.344, 19.729), interaction coefficient r=2.556. Conclusion Over 35 years of age and 1-OHP exposure are the risk factors of hypertension in coke-oven workers. There is positive interaction between age and urinary 1-OHP and its accumulation.%目的：通过分析年龄和尿1-羟基芘（1-OHP）及其交互作用与焦炉工人高血压患病率的关系，进一步探讨焦化工人高血压发病的可能机制。方法选取山西某焦化厂343名焦化作业工人为研究对象，使用统一的调查表收集个人基本信息，静息状态下检测血压3次，高效液相色谱仪检测研究对象尿1-OHP浓度。结果按尿1-OHP浓度三分距法将研究对象分为低暴露组（≤1.52μmol/molCr）、中暴露组（＞1.52～3.88μmol/mol-Cr）和高暴露组（≥3.88μmol/molCr），高血压患病率分别为13.6%、17.5%和27.7%，其中高暴露组高血压患病率显著高于低暴露组，差异有统计学意义（P＜0.05）；多因素Logistic回归分析结果显示，＞35岁与高暴露为高血压的危险因素，二者存在超相乘模型的正向交互作用，OR（95%CI）为6.800（2.344，19.729），交互系数r＝2.556。结论焦炉工人＞35岁年龄和高暴露尿1-OHP为焦炉工人高血压的危险因素，且年龄与尿1-OHP及其蓄积作用均存在正交互作用。
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