前动力蛋白2在心血管病变中的研究进展

摘要

Cardiovascular diseases are characterized by cardiac and vascular dysfunction. Prokineticin 2 ( PK2 ) is a newly found secretory peptide which plays a key role in the physiology homeostasis via prokineticin receptor 1 and 2 ( PKR1 and 2). Furthermore, PK2/PKR1 signaling pathway plays an important role in protecting cardiovascular diseases. Here we discuss the effect of PK2/PKR1 signaling in myocardial infarction, conges-tive heart failure and vascular endothelial dysfunction.%心血管疾病是以心脏和血管发生病理性改变的一类疾病.前动力蛋白2(prokineticin 2, PK2)是新近发现的一种分泌型蛋白,通过与受体(prokineticin receptor, PKR)1 和2结合,参与机体多种生理功能.研究显示,PK2/PKR1 信号通路在心血管疾病方面具有重要作用.该文就PK2/PKR1信号通路在心肌梗死、心衰和血管内皮功能紊乱等方面的研究进展进行综述.