iGluR expression in the hippocampal formation, entorhinal cortex, and superior temporal gyrus in Alzheimer’s disease

摘要

Alzheimer’s disease(AD)constitutes the largest proportion of dementia worldwide,with a significant associated medical burden.The major pathological hallmarks of AD include the gradual accumulation and deposition of amyloid-beta(Aβ)plaques and hyperphosphorylated tau protein(Revett et al.,2013).Whilst investigations centered around the tau and Aβhypothesis have been the main focus for the previous decades,the lack of therapeutic solutions has pushed for research into other potential therapeutic targets.