Novel insights into the pathogenesis of tendon injury:mechanotransduction and neuroplasticity

摘要

Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to complete tendon rupture.They involve inflammation and lead to loss of motion.In chronic conditions(or tendinopathy),symptoms include changes in both locomotor and sensorial functions of the tendon(Nourissat et al.,2015;Scott et al.,2020).Inconsistency in terminology for cases of painful tendon disorders is found,but recently the term tendinopathy was established in consensus as preferable for cases with persistent tendon pain and loss of function related to mechanical loading.This term excludes a problem in clinical practice-i.e.,specification of the presence of a particular pathological or biochemical process(Scott et al.,2020).