Megastigmane glucosides isolated from Dichrocephala benthamii

摘要

The present study was designed to investigate the chemical constituents of the whole herb ofDichrocephala benthamii.A aew megastigmane glucoside (compound 1),together with its four known analogues (compounds 2-5),was obtained.Their structures were elucidated on the basis of spectroscopic analyses (UV,IR,MS,and 1D and 2D NMR).The absolute configuration of compound 1 was assigned on the basis of CD method and chemical evidence.In addition,their cytotoxicity against human hepatoma cells (HepG-2) was evaluated by the MTT method.Compound 5 showed weak activity against HepG-2,while the other compounds did not show remarkable inhibitory effects.