Basic C Experimental Study on Cheng Zai Wan for Treatment of Necrosis of the Femoral Head

摘要

Cheng Zai Wan (承载丸), a Chinese herbal preparation was administrated in the two-leg rat model of asepticnecrosis of the femoral head established by taking prednisone acetate for a long period and the osteoporosismodel rat by castration in order to explore the effects of the prescription on necrosis of the femoral head. Theresults showed that after treatment, the pitting on the surface of the femoral head disappeared, the reticularstructure with filling cells was restored; the fat droplets in bone cells or cartilage cells of the femoral headwere significantly reduced; sparse capillaries were improved, density and width of the bone trabecula wereincreased somewhat; bone mineral density, bone weight, bone strength and rigidity were significantlyincreased; and the low level of estrin was improved. It is suggested that Cheng Zai Wan has definitetherapeutic effects on aseptic necrosis of the femoral head.