Effects of Long-term Use of the Heat-clearing, Diuresis-promoting and Collateral-mediating Chinese Drugs on Changes of Proteinuria in Patients with Chronic Nephritis

摘要

Purpose: To observe and evaluate the effects of long-term use of the heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs on changes of proteinuria in patients with chronic nephritis, to analyze the influence of renal function, blood pressure, proteinuria and TCM syndrome types on therapeutic effects of the therapy, and to analyze the indications and effects of the heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs when added with small dosage of Lei Gong Teng (雷公藤 Radix et Rhizoma Tripterygii). Method: 43 cases of chronic nephritis were treated for one year with the heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs. Result: A one-year treatment showed obvious reduction of proteinuria in patients with chronic nephritis. Conclusions: 1) The heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs are effective for a long-term treatment of proteinuria in patients with chronic nephritis. 2) Additional use of Lei Gong Teng can help control proteinuria. 3) Damp-heat deeply accumulated in the kidney is one of the pathologic characteristics for chronic nephritis with the damp-heat syndrome.