EXPERIMENTAL STUDY ON EFFECT OF TRADITIONAL BONE-KNITTING DRUGS ON TRAUMATIC GU BI (BONE-RHEUMATOID LESIONS)

摘要

Traditional bone--knitting drugs (TBKD) are used frequently in the treatment of bone frac-tures. An animal model of Gu Bi (bone--related rheumatoid lesions) with defects of articularcartilage as the main lesion was developed by surgical trauma under the stereomicroscope inWistar rats and treated with TBKD. The results showed that TBKD could promoteproliferation of cartilage cells around the traumatic site and improve the osteogenetic func-tion in the traumatic state, suggesting that TBKD can be used in combination with otherChinese drugs to treat Gu Bi, including bony lesions of the late--stage rheumatoid arthritisand bony arthritis. But the experimental results also suggested that TBKD might have an ef-fect of promoting development of inflammation, and therefore, should be used with care inthe acute phase of inflammation.