Pravastatin activates platelet nitric oxide synthase (NOS) in patients with type 2 diabetes mellitus and NOS activation is accompanied by serine phosphorylation

摘要

@@ Statins cause reductions in myocardial infarction and also morbidity and mortality of type 2 diabetes related to atheromatous disease and its thrombotic complications beyond those predicted by reductions in low density lipoprotein cholesterol (LDL).1,2 It has been suggested that the protective mechanism(s) may relate to improved endothelial function and/or antithrombotic effects, but the mechanism is not clear.