Effects of arsenic trioxide on voltage-dependent potassium channels and on cell proliferation of human multiple myeloma cells

摘要

＜正＞ Arsenic trioxide（ATO）can induce cellular apoptosisand inhibit the activities of multiple myeloma（MM）cells in vitro,1 but how it works is not very clear.Recentstudies showed that ATO worked on the voltage-dependent potassium channel and L-type calcium channelin myocardial cells,but the effect of ATO on ionchannels of tumor cells was rarely reported.As thepotassium channel plays an important role in controllingcell proliferation,we studied the effects of ATO on thevoltage-dependent potassium current（Ikv）of thevoltage-dependent potassium channel in an MM cell line,and probed into the relationship between changes of theIkv caused by ATO and cell proliferation.