Age-based clinical and angiographic outcomes after sirolimus-eluting stent implantation in patients with coronary artery disease

摘要

＜正＞ Background Advanced age independently predicts early and late mortality and major adverse cardiac events （MACE）after percutaneous coronary intervention （PCI）.Randomized clinical trials indicate that sirolimus-eluting stent （SES）implantation reduces target lesion revascularization （TLR）,but there are limited data on the impact of age on outcomesfollowing SES implantation in patients with coronary artery disease （CAD） in real-world practice.Methods A total of 333 CAD patients with 453 lesions were enrolled in this study.Subjects were divided into two groupsaccording to age:a young group （＜65 years old,244 patients with 369 lesions） and elderly group （≥65 years old,89patients with 113 lesions）.Clinical follow-up and quantitative coronary angiography （QCA） were performed seven monthsafter PCI.Results Baseline clinical,demographic,angiographic,and procedural chararcteristics were similar in both groups,except that there were more female patients in the elderly group （21.3% vs 9.8%,P=0.006）.Primary success rate wassimilar in both groups （96.5% in young group vs 95.7% in elderly group,P＞0.05）.During angiographic follow-up at 7months,binary in-stent restenosis and in-segment restenosis rates were not significantly different between the twogroups （4.7% vs 1.8%;9.7% vs 8.8%,P＞0.05 respectively）.Both sub-acute and late thrombosis rates were similar in thetwo groups （0.3% vs 0.9% and 1.2% vs 0.9%,P＞0.05 respectively,）.TLR was not significantly different between the twogroups （6.5% vs 3.5%;P=0.246）.The rates of bleeding,stroke,angina rehospitalization during the follow-up period werealso similar in both groups （P＞0.05 respectively）.Conclusion Despite a high-risk clinical profile,coronary SES implantation can be safely and effectively performed inelderly patients with a similar procedural success rate,a low complication rate,and excellent 7-month outcomes.