Risk factors for delayed graft function in cardiac death donor renal transplants

摘要

Background Delayed graft function (DGF) is common in kidney transplants from organ donation after cardiac death (DCD) donors.It is associated with various factors.Determination of center-specific risk factors may help to reduce the incidence of DGF and improve the transplantation results.The aim of this study is to define risk factors of DGF after renal transplantation.Methods From March 2010 to June 2012,56 cases of recipients who received DCD kidneys were selected.The subjects were divided into two groups:immediate graft function (IGF) and DGF groups.Transplantation factors of donors and recipients as well as early post-transplant results of recipients were compared between the two groups.Results On univariate analysis,preoperative dialysis time of recipients (P＜0.001),type of dialysis (P=0.039),human leucocyte antigen (HLA) mismatch sites (P＜0.001),the cause of brain death (P=0.027),body mass index (BMI) of donors (P＜0.001),preoperative infection (P=0.002),preoperative serum creatinine of donors (P ＜0.001),norepinephrine used in donors (P ＜0.001),cardiopulmonary resuscitation (CPR) of donors (P ＜0.001),warm ischemia time (WIT) (P＜0.001) and cold ischemia time (CIT) (P＜0.001) showed significant differences.Recipients who experienced DGF had a longer hospital stay,and higher level of postoperative serum creatinine.Conclusion Multiple risk factors are associated with DGF,which had deleterious effects on the early post-transplant period.