High Killips Class as a Predictor of New-onset Atrial Fibrillation Following Acute Myocardial Infarction: Systematic Review and Meta-analysis

摘要

Background:Recent observational studies have shown that patients with higher Killips score (＞Ⅰ) have higher risk of new-onset atrial fibrillation (NOAF) following acute myocardial infarction (AMI),while others drew a neutral conclusion.The ultimate predictive value of high Killips class on NOAF remained obscure.Methods:PubMed,Web of Science,China National Knowledge Infrastructure,and the Cochrane Controlled Trials Register Databases were searched until February 2015.Of the 3732 initially identified studies,5 observational studies with 10,053 patients were analyzed.Results:The meta-analysis of these studies showed that higher Killips score on admission was associated with higher incidence of NOAF following AMI (odds ratio =2.29,95％ confidence interval 1.96-2.67,P ＜ 0.00001),while no significant differences exist among individual trials (P =0.14 and I2 =43％).Conclusions:Killips class ＞Ⅰ was associated with the higher opportunity of developing NOAF following AMI.