Glutathione S-transferase P1 Ile105Val Polymorphism and Male Infertility Risk: An Updated Meta-analysis

摘要

Background:Several studies concerning the association between glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and male infertility risk have reported controversial findings.The present study was aimed to explore this association using a meta-analysis.Methods:The PubMed,EMBASE,China National Knowledge Infrastructure (CNKI),and Wanfang databases were searched.Odds ratios (ORs) with 95％ confidence intervals (CIs) were calculated to estimate the strength of the association.Results:A total of 3282 cases and 3268 controls in nine case-control studies were included.There was no significant association between GSTP1 Ile105Val polymorphism and male infertility in the overall population,but significant associations were found under the dominant (OR =1.23,95％ CI =1.04-1.46,I2 =32.2％) and heterozygote (OR =1.29,95％ CI =1.08-1.53,I2 =26.8％) models after excluding studies for which the data did not satisfy Hardy-Weinberg equilibrium (HWE).Similarly,subgroup analyses revealed no significant association in Asians or Chinese population although a significant association was apparent among Chinese population in studies with HWE under the heterozygote model (OR =1.25,95％ CI =1.03-1.52,I2 =44.1％).Significant heterogeneity could be observed in some genetic models,but this heterogeneity was not significant when stratified by HWE.No evidence for publication bias was found.ConcLusions:The GSTP1 Ile105Val polymorphism might not be associated with male infertility risk,and thus additional well-designed studies with larger sample size are warranted.