Influence of erectile dysfunction course on its progress and efficacy of treatment with phosphodiesterase type 5 inhibitors

摘要

＜正＞ Background Erectile dysfunction （ED） is a common impairment among older men,and the prevalence rates increasesharply after age of 60 years.Most studies have focused on the prevalence rate or dangerouse factors.The aim of thisstudy was to investigate the basic epidemiologic data about ED patients with different ED courses.The purpose of thisresearth was to understand the therapeutic effect of phosphodiesterase type 5 inhibitor （PDE5-I） and see how and whythe ED course impact the progress of ED and the therapeutic effect of PDE5-I treatment.Methods From June 2008 to June 2009,4252 questionnaires （Quality of Erection Questionnaire,QEQ） were gatheredfrom 46 centers by urology or andrology doctors all around China.Patients with ED （age ≥ 20 years） filled in first half ofthe questionnaires when they came for the first time,and then completed the second half 4 weeks after PDE5-I therapy.Results ED courses of most patients were less than 5 years （＜5 years,74.0%;5-10 years 20.8%;＞10 years,5.2%）.AsED course increasing,the incidence of the risk factors of ED,such as smoking,drinking,hypertension,diabetes,heartdisease and hyperlipidemia also increase （P＜0.01）.PDE5-I was effective in improving the quality of sexual activities （P＜0.01）.Administration of PDE5-I improves satisfaction,enjoyment and frequency of sexual activities.The longer the EDcourse,the worse the therapeutic effect （＜5 years,96.1%;5-10 years,94.9%;＞10 years,89.0%） （P＜0.01）.Conclusions The ED course greatly affected the therapeutic effect of PDE5-1,the patients with ED should consultdoctor at early stage of the disease.Admistration of PDE5-I effectively improves the penile erection and the quality ofsexual life of the patients hence should be considered as first-line medicine in the treatment of ED.