The prognostic impact of 1p21 deletion on newly diagnosed multiple myeloma patients receiving thalidomide-based first-line treatment

摘要

Objective To explore the deletion rate,clinical correlation and prognostic significance of 1p21 deletion,a novel genetic prognostic index,in patients with multiple myeloma (MM) .Methods The interphase fluorescence in situ hybridization (I-FISH) was performed on purified CD138+plasma cells from 78 newly diagnosed patients from Sept 2007 to Sept 2012 receiving thalidomide-based chemotherapy by using BAC probe covered 1p21.2 region that contains the human cell division cycle 14A