Mutation analysis of DJ-1 in patients with early-onset Parkinson’s disease and relationship between the g. 168₁85del polymorphism and Parkinson’s disease

摘要

Objective To evaluate the prevalence of the DJ-1mutation in early-onset Parkinson’s disease （EOPD） patients,and analyzed the association between the certain polymorphic marker g.168₁85del in intron 1 and Parkinson’s disease （PD） .Methods We screened all 7exons and exon-intron boundary regions of DJ-1 by PCR and direct nucleotide sequencing in 90 Chinese patients with EOPD.We also compared the allele and genotype frequencies of the g.168₁85del polymorphism between