Four stable and reliable TLC methods were established to control the quality of four traditional Chinese medicine in Siwei Chuanxinlian ultra fine powder.The reference drug,andrographolide and dehydroandrographolide were identified for the quality control of andrographolide.The indirubin was identified for the quality control of foliumisatidis.The rutin was identified for the quality control of gourd tea.The quercetin was identified for the quality control of herba polygoni pubescentis and gourd tea.The correlative extraction method and TLC method were optimised and the negative samples were prepared for comparison.The results showed that the TLC methods had no negative interference,these methods were simple and stable,they can effectively control the quality of Siwei Chuanxinlian ultra fine powder.%为控制四味穿心莲超微粉的质量,分别对其所含的四味药材进行薄层鉴别研究.通过穿心莲对照药材、穿心莲内脂和脱水穿心莲内脂的鉴别对穿心莲进行质量控制;通过靛玉红的鉴别对大青叶进行质量控制;通过芦丁的鉴别对葫芦茶进行质量控制;通过槲皮素的鉴别对辣蓼和葫芦茶进行质量控制.试验筛选并优化了相关提取方法和色谱条件,并分别制备对应的阴性样品溶液进行对比.结果表明,四种薄层鉴别方法均无阴性干扰,且简单、稳定,可以有效控制四味穿心莲超微粉的质量.
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