文章亮点： 1此问题已知的信息：细菌纤维素具有高结晶度、高亲水性、高纯度、良好的生物相容性、透明度、无毒性、超细的三维纳米纤维结构、大的比表面积、无致敏性，使它在各个领域得到广泛应用，特别是在生物材料和生物技术方面的应用，但细菌纤维素本身没有抗菌活性，它不能阻止伤口感染。 2文章增加的新信息：将细菌纤维素与纳米银颗粒结合起来形成复合膜，充分利用细菌纤维素来源广泛、成本低，而纳米银颗粒抗菌性能强的特性，2者结合形成的抗菌敷料可减少伤口感染和愈合时间，减少换药次数和患者疼痛。 3临床应用的意义：探讨了细菌纤维素与纳米银形成复合膜的3种复合方式及各自在临床应用方面的意义，加速复合膜在临床实践中的应用。%BACKGROUND:In recent years, bacterial celulose modified by nano-composite technology has been endowed with new properties. OBJECTIVE:To review the combination of bacterial celulose and nanosilver to prepare wound dressing. METHODS: A computer-online search was performed in PubMed (2013-01/2015-04) and CNKI (2007-01/2015-04) databases to retrieve studies on bacterial celulose, nanosilver and their compound method and application using the key words of “bacterial celulose, nano-silver” in English and Chinese, respectively. RESULTS AND CONCLUSION:Bacterial celulose/nano-silver compound can be prepared by three methods: solution impregnation, in situ composite and biocomposite. Solution impregnation method can lower the concentration of nanosilver ions in the fiber matrix to highly control the release of silver ions, but the genetic toxicity and biocompatibility are unclear.In situcomposite method can reduce the damage to the mesh structure of celulose on which silver ions can be bonded firmly to reduce the toxic damage to cels, but the reducing agent used has a higher toxicity, which is difficult to remove. Biocomposite method cannot produce toxic substance, which is friendly to the environment, and the synthetic biomaterials have less harm to the human body and can be controled highly.
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