1,1-二氘代-3,6,9,12-四氧代-1-二十四烷醇的合成

摘要

Methyl 3,6,9,12-tetraoxatetracosanotate reacted with lithiun aluminum deuteride in dry ethyl ether to form 3,6,9,12-tetraoxatetracosan-1,1-2d-1-ol which would be used characteristically as the reagent of isotope trace.%二缩三乙二醇在金属钠存在下与溴代十二烷反应生成3,6,9-三氧代-二十烷醇,收率86%;该醇与氯乙酸甲酯反应生成3,6,9,12-四氧代二十四烷酸甲酯,收率60%;3,6,9,12-四氧代二十四烷酸甲酯与氘代铝锂氢在乙醚中反应生成1,1-二氘代-3,6,9,12-四氧代-1-二十四烷醇,收率95%.