3,3'-二磺酸钠4,4'-二氟苯砜的合成

摘要

3,3'-Disulfonated-4,4'-difiuorodiphenyldisulfone sodium salt in total yield of 57％ was synthesized by reaction of fiuorobenzene with thionyl chloride in the presence of NaClO4 to afford 4,4'-difluorodiphenyl sulphoxide, then oxidation with H2O2 in acetic acid to give 4,4'-difiuorodiphenyl sulphone, and then sulfonation with fuming sulfuric acid. The structure was confirmed by 1H NMR.%在高氯酸钠催化下,氟苯与氯化亚砜反应制得4,4'-二氟二苯亚砜(2);2经H2O2氧化制得4,4'-二氟二苯砜(3);3用发烟硫酸磺化合成了3,3'-二磺酸钠4,4'-二氟苯砜,总收率57%.其结构经1H NMR确证.