基质金属蛋白酶及Ⅳ型胶原在胃癌中的表达及其意义

摘要

目的探讨基质金属蛋白酶(MMP2)及Ⅳ型胶原与胃癌浸润转移的关系。方法对27例胃癌患者采用临床观察及免疫组化方法观察MMP2及Ⅳ型胶原在癌组织中的表达。结果MMP2在低分化腺癌、管状腺癌的癌细胞和癌间质中表达率分别为85．7％、77．7％，同时有Ⅳ型胶原的破坏；在血管淋巴管癌栓及淋巴结转移癌病例中表达率分别为83．3％、86．7％。结论 MMP2的高表达与胃癌浸润和转移有关，主要是破坏细胞外间质，尤其是Ⅳ型胶原。MMP2监测可做为判断患者预后的指标。%Objective To evaluate the relationship between the expression of MMP2, type IV callagen, and invasion and metastasis of gastric cancer． Mothods The expression of MMP2 and Type IV collagen was observed by using immunohistochemistry technique． Results The MMP2 expression clearly appeared in the poordifferentiated adenocarcinoma and tubular adenocarcinoma(85．7 %, 77．7 % )． Type IV collagen destruction was observed simultaneously． MMP2 was highly expressed in patients with cancer embolus in blood vessel and lymphatic vessel or with lymph node metastasis (83．3 %, 86．7 % )． Conclutions The high expression of MMP2 was significantly associated with infiltration and metastasis of gartric cancer． The extracellular matrix, especially type IV collagen was destructed in the cases of high expression of MMP2． These rusults suggest that monitoring the level of MMP2 expression may be an index for evaluation of prognosis．