通脉汤治疗高危人群围术期下肢深静脉血栓形成疗效分析

摘要

Objective To investigate the effect of Tongrnai Decoction on deep venous thrombosis (DVT) of lower extremity in high risk patients.Methods The patients with complication of lower extremity fractures after operation (84 cases) were randomly divided into treatment group and control group (n =42).The patients in control group were treated with low molecular weight heparin.The patients in treatment group were treated with Tongmai Decoction based on the control processing.The D-dimer (D-D) indicators and blood flow indices were compared between two groups before and after treatment.Results The total effective rates were 95.24％ in the treatment group and 76.19％ in the control group (P =0.013).The D-D [(221.25 ± 32.78) and (152.45 ± 25.98)ng/mL],fibrinogen [(212.22 ± 22.45) and (122.36 ± 15.23) g/L],low shear rate of whole blood viscosity [(9.86 ± 1.74) and (4.36 ± 0.85) mPa · s] and high shear rate of whole blood viscosity [(5.72 ± 1.63) and (3.63 ± 0.85) mPa.s] of treatment group on day 3 and 7 after treatment were lower than those in the control group [(278.96 ± 28.96) and (211.25 ± 21.96) ng/mL,(289.36 ± 34.63) and (228.69 ± 28.36) g/L,(12.67 ± 1.46)and (9.52 ± 0.96) mPa · s,(8.37 ± 1.72)and (6.32 ± 1.21) mPa · s].Conclusion Tongrnai Decoction can effectively improve the D-D level and antiplatelet aggregation in DVT patients and improve the therapeutic effect of DVT,which is safe and reliable.%目的:探讨通脉汤治疗高危人群下肢深静脉血栓形成(DVT)的效果.方法:下肢骨折术后并发DVT的84例患者,根据随机数字表分为观察组及对照组各42例,对照组给予低分子肝素治疗,观察组在对照组基础上给予通脉汤治疗,对比治疗前后两组D-二聚体(D-D)及各血流指标的变化.结果:观察组总有效率95.24％,对照组76.19％ (P=0.013).观察组治疗后3d、7d血浆D-D[(221.25±32.78)、(152.45±25.98) ng/mL]、纤维蛋白原[(212.22±22.45)、(122.36±15.23)g/L]、低切变率下全血粘度[(9.86±1.74)、(4.36±0.85) mPa.s]、高切变率下全血粘度[(5.72±1.63)、(3.63±0.85)mPa·s]均低于对照组[(278.96±28.96)、(211.25±21.96) ng/mL,(289.36±34.63)、(228.69±28.36) g/L,(12.67±1.46)、(9.52±0.96) mPa·s,(8.37±1.72)、(6.32±1.21) mPa.s].结论:通脉汤能有效改善DVT患者D-D水平及抗血小板聚集,可提高DVT治疗效果,安全可靠.