Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas

摘要

N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas 4a～4i were designed and synthesized as antitumor agents,and their structures were characterized by IR,1H NMR,13C NMR,MS and elemental analysis.The single crystal of compound 4a,C17H13FN4OS,was also determined by X-ray crystallography.Crystal data:monoclinic,space group P21/n,a =4.9401 (8),b =8.7100(15),c =36.604(6) (A),β =93.320(3)°,V=1572.4(5) (A)3,Z =4,F(000) =704,Dc =1.438 g/cm3,μt =0.228 mm-1,R =0.0600 and wR =0.1448 for 2743 independent reflections (Rint =0.0418) and 2174 observed ones (Ⅰ ＞ 2σ(Ⅰ)).The in vitro antitumor activities of compounds 4a～ 4i were preliminarily evaluated by the standard MTT assay.