运动预处理诱导脑缺血耐受机制的研究进展

摘要

Cerebral ischemia tolerance was induced by exercise preconditioning, which protected the brain from injury. The detailed mechanism of exercise preconditioning protecting cerebral ischemia injury was complicated, which involving the regulation of multiple tar-get point and multi-path, such as inhibiting cell apoptosis, promoting angiogenesis in the brain, inhibiting the excessive activation of glutam-ic acid as well as the regulation of inflammation. More mechanisms were still unknown.%运动预处理可诱导脑缺血性损伤耐受,具有显著的脑神经系统保护作用.运动预处理改善脑缺血性损伤的具体作用机制较为复杂,涉及多靶点、多途径的调控,其中抑制细胞凋亡、促进脑神经血管生成、抑制谷氨酸的过度激活以及调控炎症反应是运动预处理诱导脑缺血耐受的关键机制.然而运动预处理诱导脑缺血耐受的机制远不止于此,有待进一步研究和发现.