Objective To explore the effects of a single bout of aerobic exercise on oxidative stress and total peripheral vascular resis-tance. Methods 36 prehypertensive patients were divided into aerobic exercise group (n=18) and control group (n=18). The aerobic exercise group performed cycle ergometry at 70%maximal oxygen consumption for 30 min. Total peripheral vascular resistance (TPVR), malondial-dehyde (MDA), mean arterial pressure (MAP), vitamin C (VC) and vitamin E (VE) were measured before, immediately, 1 hour and 2 hours after the aerobic exercise. Results There was no significant difference in TPVR, MDA, MAP, VC and VE between two groups before exer-cise (P>0.05). TPVR was all significantly lower in the aerobic exercise group than in the control group immediately, 1 hour and 2 hours af-ter exercise (P<0.001), and showed a rising trend of recovery. MDA was significantly higher in the aerobic exercise group than in the con-trol group 1 hour and 2 hours after exercise (P<0.05), however there was no significant difference in MDA between two groups immediately after exercise (P>0.05). MAP was significantly lower immediately after exercise in the aerobic exercise group than in the control group (P<0.001), but there was no significant 1 hour and 2 hours after exercise (P>0.05). There was no significant difference in VC and VE between two groups immediately, 1 hour and 2 hours after exercise (P>0.05). Conclusion The level of oxidative stress increases after a single bout of aerobic exercise, and the TPVR decreases.%目的：探讨单次有氧运动对高血压前期患者氧化应激反应及总血管外周阻力的作用。方法36例高血压前期患者随机分为有氧运动组(n=18)和对照组(n=18)。有氧运动组以70%最大摄氧量行单次功率自行车运动，共30 min。对照组保持日常生活状态。两组分别于运动前、运动后即刻、运动后1 h和运动后2 h测定平均动脉压(MAP)，总外周血管阻力(TPVR)，血清丙二醛(MDA)、维生素C(VC)和维生素E(VE)含量。结果运动前两组各指标均无显著性差异(P>0.05)；运动后即刻、运动后1 h和运动后2 h，有氧运动组TPVR均较对照组显著降低(P<0.001)，但呈升高趋势；运动后1 h和2 h，有氧运动组MDA较对照组升高(P<0.05)，运动后即刻与对照组无显著性差异(P>0.05)；运动后即刻，有氧运动组MAP较对照组显著降低(P<0.001)，运动后1 h和2 h与对照组无显著性差异(P>0.05)；运动后即刻、运动后1 h和运动后2 h，有氧运动组VC和VE较对照组均无显著性差异(P>0.05)。结论单次有氧运动后氧化应激水平升高，总外周血管阻力降低。
展开▼
