完全性脊髓损伤后血清S-100β蛋白浓度的变化

摘要

目的：评价S-100β蛋白能否成为创伤性脊髓损伤的血清标记物。方法2013年6月~2014年10月，选取完全性脊髓损伤患者24例，分别在损伤后1周、3个月、6个月抽血，采用酶联免疫吸附法测定血清中S-100β蛋白浓度，以10名健康人血清作为正常对照。结果 S-100β蛋白血清浓度在损伤后1周、3个月时显著升高(Z>4.273, P<0.001)。结论 S-100β蛋白血清浓度升高可能有助于评估完全性脊髓损伤后早期的组织损伤。%Objective To evaluate whether S-100β protein could be a serum marker for traumatic spinal cord injury (SCI). Methods From June, 2013 to October, 2014, 24 patients with complete SCI were measured the serum S-100β protein concentrations with en-zyme-linked immunosorbent assay, one week, three and six months after SCI. Serum from ten healthy persons was as normal control. Re-sults The serum S-100βprotein concentrations increased one week and 3 months after SCI (Z>4.273, P<0.001). Conclusion The increase of serum S-100βprotein may help assessing early impairment after complete SCI.