Objective To explore the relationship between incidence and risk factors of poststroke depressive symptoms and characteristics before stroke. Methods 630 patients with acute transient ischemic attack or cerebral infarction were select-ed as the research subject. The manifestations of poststroke depression were assessed by the hospital anxiety and depression scale in 6~8 weeks after stroke. Multivariate regression analyses were used to evaluate the relationship between factors before stroke and symptoms of poststroke depression. Results The overall incidence of poststroke depression was 14% ,and had no obvious relationship with subtype of stroke or first-ever stroke. Poststroke nerve dysfunction was significantly related to posts-troke depression ,and relative integrity of neurological function could reduce the occurrence of poststroke depression. Conclu-sion After depression which had existed before stroke was ruled out ,poststroke depressive symptoms were not related to lesion side or location ,but is associated with nerve dysfunction and de-gree of functional independence. Early screening for poststroke depression symptoms and risk factors might help to predict long term outcome ,give an early intervention measures and promote the function recovery.%目的：探讨脑卒中后抑郁症状的发病率及危险因素与卒中前特点的关系。方法对630例伴急性临床症状的短暂性脑缺血发作或脑梗死患者，脑卒中后6～8周应用医院焦虑和抑郁量表评定卒中后抑郁症状的表现，应用多变量逻辑回归模式评估卒中前因素与卒中后症状之间的关系。结果脑卒中后抑郁症状的总体发病率14％，与卒中亚型或初次发生卒中无明显关系。卒中后的神经功能障碍与卒中后抑郁症状明显相关，神经功能的相对完整性减少卒中后抑郁症状的发生。结论排除卒中前抑郁症状后，卒中后抑郁症状与损伤位置和损伤侧别无关，但与卒中后神经功能障碍和独立程度有关，早期筛查卒中后抑郁症状及危险因素，可能对预测长期临床结果、及早进行干预措施、促进功能康复有一定帮助。
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