超重或肥胖患者脑卒中发病后生化指标改变的研究

摘要

Objective To study the biochemical index changes for different overweight or obese patients after attack of stroke.Methods 235 stroke patients were selected and divided into normal group (50 cases) ,overweight group (50 cases) , mildly obese group (50 cases) ,moderately obese group (45 cases) and severely obese group (40 cases) based on BMI. The blood lipid ,blood sugar ,UA ,Hcy as well as hemorheology of each group was observed and compared.Results With the high‐er BMI ,the levels of TC ,TG ,LDL‐C ,PBG ,UA and Hcy were gradually increased while the level of HDL‐C was gradually reduced (P<0.05);with the higher BMI ,the plasma viscosity ,low blood viscosity ,high blood viscosity ,hematocrit and e‐rythrocyte sedimentation rate was gradually increased (P<0.05).Conclusion BMI is an important prognosis index after attack of stroke. With the higher BMI ,the levels of blood lipid ,blood sugar ,UA and Hcy are increased while the hemorheology is presented as high blood viscosity.%目的：探讨不同程度超重或肥胖患者脑卒中发病后生化指标的改变。方法临床纳入脑卒中患者235例，根据患者体重指数（BM I）不同分为正常组50例，超重组50例，轻度肥胖组50例，中度肥胖组45例，重度肥胖组40例。分别观察各组血脂、血糖、血尿酸（UA）、同型半胱氨酸（Hcy）水平，并比较血流变情况。结果随着患者BMI水平的增高，其血清胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL‐C）、空腹血糖（PBG）、UA、Hcy水平呈现逐步升高趋势，而血清高密度脂蛋白（HDL‐C ）水平则出现逐步降低的趋势，差异有统计学意义（ P＜0.05）。随着患者BM I水平的增高，其血浆黏度、全血低切黏度、全血高切黏度、红细胞比积、红细胞沉降率水平呈逐步升高的趋势，差异有统计学意义（P＜0.05）。结论 BMI是影响脑卒中患者预后的一个重要指标，BMI越高患者血脂、血糖、UA、Hcy水平越高，血流变呈现高黏状态。