目的 探讨11～13+6周系统超声检查对胎儿中枢神经系统畸形的诊断价值.方法 选取2013-10—2016-07在郑州大学第二附属医院行11～13+6周早孕期超声筛查的4211个孕妇(4475个胎儿),测量胎儿头臀长(crown-rump length,CRL)、颈项透明层(nuchal translucency,NT)等,并对胎儿进行系统筛查.结果 11～13+6周系统超声筛查共检出胎儿中枢神经系统畸形44例,其中露脑畸形22例,无脑畸形9例,全前脑6例,脑膨出3例,脊柱裂2例,单纯脑积水2例;11～13+6周系统超声筛查中枢神经系统未发现明显异常,中晚孕期系统超声检查发现异常25例,其中脑积水10例,小脑发育不良6例,脊柱裂4例,全前脑2例,胼胝体发育不良2例,脑膨出1例.结论 11～13+6周胎儿系统超声筛查对胎儿中枢神经系统畸形有重要的诊断价值,所检出的阳性病例均为中枢神经系统严重畸形,仍需要中晚孕期系统超声筛查进行有效的补充.%Objective To evaluate the value of first trimester screening with ultrasound in the detection of central nerve sys-tem malformation .Methods 4211 pregnant women(4475 fetuses) undergoing first trimester screening with ultrasound from Oc-tober 2013 to July 2016 were enrolled in this study .The fetal head and hip length(CRL) ,neck transparent layer(NT) were meas-ured and the fetus was systematically screened .Results Among the 4475 fetuses ,a total of 44 cases of fetal central nervous sys-tem malformations were detected ,including 22 cases of deformities ,9 cases of anencephaly ,6 cases of full forebrain ,3 cases of brain enlargement ,2 cases of spina bifida ,2 cases of hydrocephalus .There were no significant abnormalities in the central nervous system in 11-13+6 weeks ,including 10 hydrocephalus ,6 cerebellar dysplasia ,4 spina bifida ,2 full forebrain ,2 corpus callosum dysplasia and 1 brain enlargement .Conclusion The first trimester screening fetal system is of great value in diagnosis of fetal cen-tral nervous system malformation .The positive cases are all severe malformation of central nervous system .The second trimester screening is still needed for effective supplementation .
展开▼
