目的探讨注射用脂溶性维生素（Ⅰ）、（Ⅱ）不良反应发生的特点和规律，为临床合理用药提供参考。方法检索全文期刊数据库中2001年1月至2014年5月报道，关键词为“注射用脂溶性维生素（Ⅰ）、（Ⅱ）”和“不良反应”的文献报道，并进行统计分析。结果纳入文献21篇，病例23例。其中，涉及脂溶性维生素2个品种，分别是脂溶性维生素（Ⅰ）和脂溶性维生素（Ⅱ）；50岁以上患者构成比最大，占47.82%，发生不良反应的男女性别比为1：1.09；不良反应以过敏反应致过敏性休克最常见，有16例。发生不良反应的时间多在用药后1～15min内，占56.52%；不良反应累及皮肤、呼吸、循环、神经、消化等多个系统。结论脂溶性维生素以过敏反应居多（特别是过敏性休克），不良反应与性别无关，与年龄、过敏史、用药时间有关。故在临床使用时，一定要用前询问过敏史，在遵照说明书使用的前提下，注意观察用药的不良反应，尤其是用药15分钟内的不良反应，发现不良反应及时处理，确保使用安全。%Objective To explore the characteristics and general features of adverse reactions induced by the fat soluble vitamin injections(Ⅰ)、(Ⅱ), and provide reference for rational clinical use of drugs. Methods To retrieval journals database from January 2001 to May 2014 by using keywords which are"fat soluble vitamin injections(Ⅰ) and (Ⅱ)"and"adverse reaction" reported in the literatures, then these results should be analyzed statistically. Results This paper includes 21 literatures and 23 cases. The fat soluble vitamins involve 2 varieties which are fat soluble vitamin (Ⅰ)and fat soluble vitamin(Ⅱ).The constituent ratio for patients aged 50 and above is the largest, accounting for 47.82%. The sex ratio of adverse reactions is 1: 1.09. Among adverse reactions, the allergic shock caused by the allergic reaction was the most (16 cases). The adverse reaction occurs mostly in the 1~15min, accounting for 56.52%. The adverse reaction involves the skin, respiratory, circulatory, nervous, digestive and other systems. Conclusion Adverse reaction for most of the fat soluble vitamins are allergic reactions (especially anaphylactic shock). Adverse reactions have nothing to do with the sex, relate with the age, history of allergies, and medication time. Therefore, we must ask the al lergy history clinically, and pay attention to adverse reactions, especially adverse reactions in 15 minutes. When adverse reactions occur, we should deal with the problems in time and ensure security.
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