In the reseated colon segments taken from 21 patients with Hirschsprung's disease, it is found that the level and the extent of the mucosa showing increase in AChE do not "coincide" with the aganglionic segment of colon. The level of mucosa showing increase in AChE is usually lower than the level of aganglionosis. The longerthe aganglionic segment, the greater the difference between the levels of increasing AChE and those lacking ganglions. But the increase in mucosal AChE at the level of 3 cm above the dentate line of rectum always proves to be in accordance with the aganglionic findings (95%). Therefore the aspiration biopsy should be taken at this 3 cm level. The increase in AChE in two cases of total colonic aganglionosis is neither different from that in other types of Hirschsprung's disease.%本文观察21例先天性巨结肠症切除肠管的无神经节细胞肠段与AChE活性增高范围的关系.粘膜AChE活性增高范围与无神经节细胞肠段的长度不一致,但在距齿线3cm处的直肠粘膜内均出现AChE活性增高,与病理检查比较,正确率达95%.因此,直肠粘膜吸引活检时以距齿线3cm处取材,阳性率高.
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