Objective To investigate the serum vitamin D level in elderly men in Shanghai and the relationship between serum vitamin D and PTH level and bone turnover markers.Methods Eight hundred and ninety-five elderly men ( mean age 76 years) , who attended the geriatric department in Shanghai Ruijin Hospital from September 2010 to September 2013, were enrolled.Serum 25-hydroxy vitamin D [ 25-( OH ) D ] , calcium ( Ca ) , phosphorus ( P ) , parathyroid hormone ( PTH ) , procollagen type I N-terminal propeptide ( PINP), and β-crosslaps of C-telopeptide of type I collagen (β-CTX) were measured.Four groups were divided according to their serum 25(OH)D levels, including severe deficiency group ( <5 nmol/L), deficiency group (25 -50 nmol/L), insufficiency group (50-75 nmol/L), and sufficiency group (>75 nmol/L).Results (1) The mean age of the 895 subjects was 76 years old (from 60 to 99 years).The average level of 25(OH)D was 43.52 ±21.97 nmol/L.Subjects of vitamin D deficiency (≤50nmol/L) and insufficiency (50 -75 nmol/L) were 592 (67%) and 223 cases (25%), respectively.The amount of vitamin D deficiency and insufficiency was up to 92%.Subjects of vitamin D sufficiency (75 nmol/L) were only 80 cases (8%).(2) Serum 25(OH)D in different ages showed that 25(OH) D level decreased with an increase of age and the highest level was in 60 -69 -year group ( 46.27 ±20.76 ) .This was significant different compared to other age groups ( P<0.05).Correlation analysis showed that serum 25(OH)D level was negatively correlated with age (r=-0.088,P=0.008).(3) The mean level of PTH was 55.74 ±29.06.Correlation analysis showed that serum 25( OH) D level was negatively correlated with PTH, PINP, andβ-CTX (r=-0.209, -0.109, and -0.122, P<0.05) and had no correlation with BMI and P (P>0.05). Serum 25(OH) D level was positively correlated with Ca (r =0.206, P <0.001).Conclusion Vitamin D deficiency or insufficiency is highly prevalent in elderly men.Serum 25 ( OH) D level is negatively correlated with PTH, age, PINP, and β-CTX.%目的：探讨老年男性血清维生素D水平及其与甲状旁腺素及骨代谢指标的相关性。方法收集2010年9月至2013年9月在上海瑞金医院老年病科病房住院及门诊患者895例，平均年龄为76岁。测定其血清25－羟基维生素D[25（OH）D]、血钙（Ca）、血磷（P）、甲状旁腺激素（PTH），I型胶原分子N－端前肽（PINP）及β－I型胶原C端肽（β－CTX）水平。根据血清25（OH）D水平将患者分为维生素D严重缺乏组（＜25 nmol／L）、维生素D缺乏组（25～50 nmol／L）、维生素D不足组（50～75 nmol／L）和维生素D充足组（＞75 nmol／L）。结果（1）895例老年男性患者年龄60～99岁，平均年龄76岁。血清25（OH）D平均值为（43．52±21．97）nmol／L。维生素D缺乏者（≤50nmol／L）为592人（67％），维生素D不足者（50～75 nmol／L）为223人（25％）。维生素D缺乏或不足者高达92％，维生素D充足者（＞75 nmol／L）仅为80人（8％）。（2）不同年龄段血清25－（OH）D的比较显示，血清25－（OH）D水平随增龄而逐渐降低。60～69岁组25－（OH）D值最高，为（46．27±20．76）nmol／L，与其它各组比较差异均有统计学意义（P＜0．05）。相关分析表明，血清25－（OH）D与年龄呈负相关（相关系数r＝－0．088，P＝0．008）。（3）甲状旁腺素（PTH）的平均水平为（55．74±29．06）pg／ml。相关分析显示，25－（OH）D与PTH、PINP、β－CTX均呈负相关（r值分别为－0．209、－0．109、－0．122，P均＜0．05）。血25－（OH）D与Ca呈正相关（r＝0．206，P＜0．001）。血25－（OH） D与BMI、P均无相关性（ P均＞0．05）。结论老年男性存在严重的维生素D缺乏或不足。血25－（ OH ） D与PTH、年龄、PINP、β－CTX均呈负相关。
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