我国正常人多焦视网膜电图的特征

摘要

Objective　To test the characteristics of multifocal ERG in normal Chinese subjects and to provide reference values in clinical application.Methods　The multifocal ERGs by using VERIS 4.0 visual evoked response imaging system were tested for 42 subjects (48 eyes). Their ages ranged from 11 to 67 years (mean, 40.7 years). The stimulative visual angles subtended ±26.6° horizontally and ±22.1° vertically. Burian-Allen contact lens electrode was used to record the responses from 103 retinal locations in 8 min (16 segments). Results With age increasing, the latencies of N1 wave and P1 wave delayed, there were statistically significant differences of the latencies between <50 year group and ≥50 year group (t>2.01，P<0.05), and the amplitude densifies of N1 wave and P1 wave decreased with wide inter-individual variation. The amplitude densities of N1 wave and P1 wave were greatest at the central fovea, they were (44.88±13.30) nV/deg2, (70.90±17.77) nV/deg2 respectively, the densities reducing towards more peripheral location. The amplitude sum of N1 wave at the upper retina were greater than that at the lower retina, and the amplitude densities and sums of N1 wave and P1 wave at superior-temporal quadrant were greater than that at inferior-nasal quadrant. Conclusion　Our results suggest multifocal ERG be able to reflect the visual function at different retinal locations correctly and objectively and provide normal reference limits.%目的　检测我国正常人多焦视网膜电图（electroretinogram, ERG）的特征，以探讨其正常参考值。方法　应用VERIS 4.0视诱发反应图像系统检测42例(48只眼)正常人多焦ERG，检测对象年龄11～67岁，平均40.7岁。检测视野的水平视角为±26.6°，垂直视角为±22.1°，采用Burian-Allen接触镜电极，于8 min (分16段)记录103个视网膜部位的反应。结果　随被检测者年龄增长，多焦ERG的N1波和P1波潜伏期延长，<50岁与≥50岁年龄组间比较差异有显著性(t值均>2.01，P值均<0.05)；N1波和P1波振幅密度降低，个体间变异较大，在中央凹N1波和P1波的振幅密度最大，分别为(44.88±13.30) nV/deg2、(70.90±17.77) nV/deg2；向周边振幅密度逐渐降低；N1波的上半视网膜的振幅总和较下半视网膜大，颞上N1波和P1波振幅密度和振幅总和均较鼻下的大。结论　多焦ERG能准确、客观地反映视网膜不同部位的功能，我们的研究结果将为临床提供正常参考值。