Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

摘要

Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118,a fungus obtained from a deep-sea sediment sample,resulted in the isolation of a known antibacterial compound,xanthocillin X (1),and 14 other known compounds comprising three steroids (2-4),two ceramides (5 and 6),six aromatic compounds (7-12),and three alkaloids (13-15).Xanthocillin X (1) was isolated for the first time from a marine fungus.In the bioassay,xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli,and significant cytotoxicity against MCF-7,HepG2,H460,Hela,Du145,and MDA-MB-231 cell lines.Meleagrin (15) exhibited cytotoxicity against HepG2,Hela,Du145,and MDA-MB-231 cell lines.This is the first report of the cytotoxicity of xanthocillin X (1).